The Best Weight Loss Injections, Reviewed
I've put together this guide after carefully reviewing the leading GLP-1 receptor agonists for weight management. I've focused on what matters most: how well they work, their safety profiles, and what real users have to say about their experiences.
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2
Wegovy
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FDA-approved specifically for weight loss and chronic weight management
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Weekly injection with proven results
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Once-weekly injection (no daily dosing required)
4.2
My research showed that Wegovy users consistently praise its effectiveness for weight loss and appetite control. In clinical trials, people lost nearly 6% of their body weight within three months and around 11% within six months. Users report significantly reduced appetite and fewer cravings, even at lower doses. The medication's once-weekly injection schedule also makes it convenient compared to daily alternatives.
3
Noom
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No insurance required for access to compounded medications
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Offers both brand-name medications and compounded semaglutide
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70% of members on microdoses report no side effects at all
4.1
I looked into Noom and found that the company takes a unique approach with their microdose GLP-1 program, starting at just $99-$119 monthly. What stands out is their personalized dosing - using 25% or less of standard doses to minimize side effects. Their data shows 70% of microdose users report zero side effects while still achieving meaningful weight loss. The program combines medication with psychology-based behavioral coaching and includes their "Muscle Defense" feature to help preserve lean muscle during weight loss.
4
Fridays Health
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No hidden fees, membership costs, or lab charges
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Holistic approach combining medication with lifestyle coaching
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Monthly or three-month subscription plans available
4.1
Friday Health focuses heavily on their holistic approach, offering compounded semaglutide at $249 monthly with no hidden fees or extra lab charges. What stands out to me is their comprehensive support system - you get weekly coaching sessions, 24/7 messaging access to your care team, and support covering nutrition, mental health, and movement.
5
Sprout
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Does not accept insurance - cash-pay only
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Ships to all 50 states
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Also offers NAD+ injections for energy and vitality
4.0
Sprout Health offers a straightforward cash-pay model with compounded semaglutide at $249 monthly and tirzepatide at $299, with $50 off your first month. What I find appealing is their price-lock guarantee - your rate stays the same even if your dosage increases. They don't accept insurance, which means faster processing with prescriptions sent to pharmacies within two business days. The pricing includes provider evaluations, follow-ups, messaging access, medication, and shipping with no hidden fees.
1
Ro
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Insurance navigation support
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Get qualified for Ozempic®, Wegovy® and Zepbound®
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Clinical trials show up to 15% weight loss
4.8
I found that Ro stands out for its insurance navigation support and medication flexibility. They handle all the complex paperwork and approvals for brand-name GLP-1s like Wegovy, Ozempic, and Zepbound - a process that can take weeks on your own. If insurance denies coverage, Ro may offer compounded alternatives at lower costs. This combination of insurance advocacy and access to both brand-name and compounded options makes the process significantly easier.
6
Vivim
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Requires $74.99 monthly membership fee (medication pricing is separate)
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Flexible payment options through Klarna (pay over time)
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Compounded medications not covered by insurance
3.8
They require a $74.99 monthly membership plus medication costs, and you're locked into 1-6 month commitments with no cancellation option once started. That said, their results are strong - patients lost an average of 46 pounds over 68 weeks. Their GLP-1 ID protocol offers personalized weekly dose adjustments rather than fixed dosing, and the membership includes unlimited provider access and nutrition coaching.
7
Mochi
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Large Facebook community with over 140,000 members
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Referral program offering $40 credit
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Mixed customer service reviews - good phone support but not on email
3.8
Mochi Health charges $79 monthly membership plus medication costs—$99 for compounded semaglutide or $199 for tirzepatide. They offer strong insurance support for brand-name options and access to board-certified obesity specialists and dietitians. However, they experienced major operational issues in spring 2025 with pharmacy problems causing 30+ day shipping delays. Customer service is hit-or-miss - good phone support but poor email communication. Their large 140,000+ member Facebook community provides peer support.
The compounded medications our partners offer haven't been reviewed or approved by the FDA for safety, quality, or effectiveness. Microdosing these medications for weight loss is experimental and lacks FDA approval or substantial scientific backing for this specific use. I recommend discussing with your provider whether a compounded medication fits your needs. Medications with semaglutide, tirzepatide, and liraglutide require prescriptions, which only licensed clinicians can provide if they determine it's medically appropriate for your weight loss. These drugs can cause side effects including nausea, vomiting, diarrhea, abdominal pain, and constipation—contact your provider immediately if you experience symptoms. The information here doesn't replace professional medical advice, diagnosis, or treatment, so please consult your provider with any questions or concerns.
1
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Insurance navigation support
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Get qualified for Ozempic®, Wegovy® and Zepbound®
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Clinical trials show up to 15% weight loss
4.8
Ro
After reviewing the major GLP-1 providers in the market, Ro consistently emerges as the most comprehensive option. Their insurance navigation support is unmatched - they handle all the complex paperwork and approvals for brand-name GLP-1s like Wegovy, Ozempic, and Zepbound, a process that can take weeks on your own. If insurance denies coverage, Ro offers compounded alternatives at lower costs. Combined with their clinical support, monthly check-ins, and unlimited provider messaging, this makes Ro the strongest all-around choice for most people seeking GLP-1 treatment.
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